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Evaluation of Cefuroxime Concentrations in the Lumbar Spine and Tissue of the Central Nervous System Using Microdialysis

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In this project we aimed to investigate whether the standard perioperative antibiotic prophylaxis regimen with administration of a single-dose of 1,500 mg cefuroxime results in sufficient concentrations in the tissues of the lumbar spine and the central nervous system.

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Project members

Alexander Emil Kaspersen, BSc Project leader
Magnus A. Hvistendahl, BSc Project member
Pelle Hanberg, MD PhD Project member
Mats Bue, MD PhD Project member
Maiken Stilling, MD PhD Project member
Kristian Høy, MD PhD Project member

Publications in relation to this project

  1. Evaluation of cefuroxime concentration in the intrathecal and extrathecal compartments of the lumbar spine – an experi-mental study in pigs

    Kaspersen AE, Hanberg P, Hvistendahl MA, Bue M, Schmedes AV, Høy K, Stilling M

    British Journal of Pharmacology. 2023 Jan 29. DOI: 10.1111/bph.16045

  2. Subtherapeutic perioperative levels of cefuroxime inside a cannulated pedicle screw used in spine surgery – results from a porcine microdialysis study

    Hvistendahl MA, Hanberg P, Stilling M, Kaspersen AE, Høy K, Bue M

    Acta Orthopaedica. 2022 Nov 28;93:874-879. DOI: 10.2340/17453674.2022.5276

  3. Cefuroxime concentrations in the anterior and posterior column of the lumbar spine – an experimental porcine study

    Hvistendahl MA, Bue M, Hanberg P, Kaspersen AE, Schmedes AV, Stilling M, Høy K

    The Spine Journal. 2022 Jun 6;22(9):1434-1441. DOI: 10.1016/j.spinee.2022.05.010

Last updated 24 February 2023